Importance of cytochrome P450 (CYP450) in adverse drug reactions due to drug-drug interactions: a PharmacoVigilance study in France

Eur J Clin Pharmacol. 2013 Apr;69(4):885-8. doi: 10.1007/s00228-012-1394-3. Epub 2012 Sep 21.

Abstract

Objective: Our aim was to characterize Adverse Drug Reactions (ADRs) related to drug-drug interactions (DDIs) related to involvement of cytochrome P450 (CYP450) isoenzymes in a pharmacovigilance database.

Methods: ADRs recorded by Midi-Pyrénées PharmacoVigilance center (France) between 1 January and 31 August 2008 were extracted from the French PharmacoVigilance Database (FPVD).

Results: Among the 1,205 reported ADRs, 16 (1.3 %), can be explained by involvement of CYP450 isoenzymes (including 4 "serious"). All interactions involved CYP inhibitors, mainly for CYP3A4/5.

Conclusion: The percentage of ADRs reported in the pharmacovigilance database and related to CYP450-induced DDIs appears to be relatively low (~ 1-2 %).

MeSH terms

  • Adolescent
  • Adult
  • Adverse Drug Reaction Reporting Systems*
  • Aged
  • Aged, 80 and over
  • Cytochrome P-450 Enzyme System / metabolism*
  • Databases, Factual
  • Drug Interactions*
  • Drug-Related Side Effects and Adverse Reactions / enzymology*
  • Drug-Related Side Effects and Adverse Reactions / epidemiology
  • Female
  • France / epidemiology
  • Humans
  • Isoenzymes
  • Male
  • Middle Aged
  • Pharmacovigilance*

Substances

  • Isoenzymes
  • Cytochrome P-450 Enzyme System