MYC addiction: a potential therapeutic target in MM

Blood. 2012 Sep 20;120(12):2351-2. doi: 10.1182/blood-2012-08-445262.

Abstract

In this issue of Blood, Holien et al report that MYC addiction is responsible for rapid death of myeloma cell lines and primary myeloma tumor cells treated with a specific MYC inhibitor.

Publication types

  • Comment

MeSH terms

  • Apoptosis / drug effects*
  • Cell Proliferation / drug effects*
  • Gene Expression Regulation, Neoplastic / drug effects*
  • Humans
  • Multiple Myeloma / drug therapy*
  • Multiple Myeloma / pathology*
  • Proto-Oncogene Proteins c-myc / metabolism*

Substances

  • MYC protein, human
  • Proto-Oncogene Proteins c-myc