Abstract
Learning to let go with age: Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto-oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence-associated β-galactosidase (SA-β-gal), and releases the cargo upon entry into SA-β-gal expressing cells.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cell Line, Tumor
-
Cellular Senescence
-
Drug Delivery Systems / instrumentation
-
Drug Delivery Systems / methods*
-
Fluorescent Dyes / administration & dosage
-
Fluorescent Dyes / chemistry
-
Humans
-
Nanoparticles / chemistry*
-
Porosity
-
Rhodamines / administration & dosage
-
Rhodamines / chemistry
-
Silicon Dioxide / chemistry*
-
beta-Galactosidase / chemistry
-
beta-Galactosidase / metabolism
Substances
-
Fluorescent Dyes
-
Rhodamines
-
Silicon Dioxide
-
beta-Galactosidase
-
rhodamine B