In this article, the authors discuss the extent of HCV infections and the obstacles people with concurrent mental health and substance disorders face in terms of access to care in urban areas. The authors remind that HCV is associated with a reduced quality of life and an increased risk of cirrhosis, but that new treatments developed over the last decade can lead to the eradication of the virus and to the prevention of complications. The authors also describe the steps leading to the establishment of an HCV treatment program at the Centre hospitalier de l'Université de Montréal (CHUM).