A covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid β

Chem Commun (Camb). 2012 Nov 4;48(85):10565-7. doi: 10.1039/c2cc35178a.

Abstract

Lys16 is present in the core region of the amyloid β (Aβ) self-assembly in Alzheimer's disease. Here we report that the P9-NCS peptide can covalently react with Lys16 and inhibit Aβ neurotoxic fibrillization. Moreover P9-NCS has high selectivity and it cannot react with amylin, insulin, fetal bovine serum, Q11 and MUC1 peptide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amyloid beta-Peptides / chemistry
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Lysine / metabolism
  • Mice
  • Peptide Fragments / chemistry
  • Peptide Fragments / metabolism
  • Peptides / chemistry
  • Peptides / metabolism*
  • Peptides / pharmacology
  • Protein Binding

Substances

  • Amyloid beta-Peptides
  • Peptide Fragments
  • Peptides
  • amyloid beta-protein (1-42)
  • Lysine