Splenic marginal zone lymphoma in a HIV-1 infected patient: evidence favouring a pathogenetic role of HIV-1 itself in the lymphomagenesis

M Cagliuso; V Conti; S Trasarti; L Lombardi; M Riminucci; M Perez; O Turriziani; F Falasca; M Nanni; A Tafuri; I Mezzaroma

doi:10.1007/s15010-012-0344-4

Splenic marginal zone lymphoma in a HIV-1 infected patient: evidence favouring a pathogenetic role of HIV-1 itself in the lymphomagenesis

Infection. 2013 Feb;41(1):255-8. doi: 10.1007/s15010-012-0344-4. Epub 2012 Sep 25.

Authors

M Cagliuso¹, V Conti, S Trasarti, L Lombardi, M Riminucci, M Perez, O Turriziani, F Falasca, M Nanni, A Tafuri, I Mezzaroma

Affiliation

¹ Department of Clinical Medicine, Sapienza University of Rome, Viale dell'Università 37, 00185, Rome, Italy.

PMID: 23007326
DOI: 10.1007/s15010-012-0344-4

Abstract

A rare case of splenic marginal zone lymphoma (SMZL) in a human immunodeficiency virus (HIV)-1 infected patient is described. As an association between SMZL and viral infections has been reported, the presence of the hepatitis C virus and HIV-1 genomes was evaluated. Only HIV-1 DNA levels were detected in enriched splenic B lymphocytes, suggesting a HIV-1 involvement in lymphomagenesis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Cell Transformation, Viral
Female
HIV Infections / complications*
HIV Infections / drug therapy
HIV Infections / virology
HIV-1 / pathogenicity*
Humans
Lymphoma, B-Cell, Marginal Zone / diagnosis
Lymphoma, B-Cell, Marginal Zone / etiology*
Middle Aged
Spleen / pathology
Splenic Neoplasms / diagnosis
Splenic Neoplasms / etiology*