Abstract
A pytochemical study on the constituents of the roots of Symphyotrichum subulatum led to the isolation of three new compounds including two diacetylenes, asterynes A (1) and B (2), and (E)-4-(3-acetoxyprop-1-enyl)-2-methoxyphenyl (S)-2-methylbutanoate (3) along with twelve known compounds. Their structures were elucidated with spectroscopic analyses. Compound 3 showed anti-inflammatory activity on LPS-induced NO production with an EC50 value of 15.0 µM.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylene / analogs & derivatives
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Acetylene / chemistry*
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Acetylene / isolation & purification*
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Acetylene / pharmacology
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Asteraceae / chemistry*
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Butyrates / chemistry
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Butyrates / isolation & purification
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Drug Evaluation, Preclinical
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Lipopolysaccharides / adverse effects
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Macrophages / chemistry
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Macrophages / drug effects
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Nitric Oxide / chemistry
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Phenol / chemistry*
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Phenols / chemistry
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Phenols / isolation & purification
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Plant Extracts / chemistry
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Plant Roots / chemistry
Substances
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(E)-4-(3-acetoxyprop-1-enyl)-2-methoxyphenyl (S)-2-methylbutanoate
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Anti-Inflammatory Agents, Non-Steroidal
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Butyrates
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Lipopolysaccharides
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Phenols
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Plant Extracts
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asteryne A
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Nitric Oxide
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Phenol
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Acetylene