Abstract
Streptococcus pneumoniae serotype 1 presents a high invasiveness index and is seldom isolated from its niche, the nasopharynx. We report an unusual serotype 1 carriage in a healthy pediatric population at the time of the heptavalent pneumococcal vaccine adoption in Belgium. Our sampling period coincides with an epidemic wave of serotype 1 invasive pneumococcal infections. Invasive and colonizing isolates were characterized by both antibiotic resistance profile and multilocus sequence typing and were shown to share the same backbone (ST306 and ST350).
MeSH terms
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Belgium / epidemiology
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Carrier State / epidemiology
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Carrier State / microbiology*
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Child
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Child, Preschool
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Epidemics
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Heptavalent Pneumococcal Conjugate Vaccine
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Humans
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Microbial Sensitivity Tests
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Multilocus Sequence Typing
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Pneumococcal Infections / epidemiology
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Pneumococcal Infections / microbiology*
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Pneumococcal Vaccines
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Prospective Studies
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Serotyping
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Streptococcus pneumoniae / classification*
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Streptococcus pneumoniae / drug effects
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Streptococcus pneumoniae / isolation & purification
Substances
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Heptavalent Pneumococcal Conjugate Vaccine
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Pneumococcal Vaccines