Abstract
Influenza C virus replicates more efficiently at 33°C than at 37°C. To determine whether hemagglutinin-esterase-fusion protein (HEF), a surface glycoprotein of influenza C virus, is a restricting factor for this temperature sensitivity, we analyzed the biological and biochemical properties of HEF at 33°C and 37°C. We found that HEF exhibits intrinsic temperature sensitivities for surface expression and fusion activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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COS Cells
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Chlorocebus aethiops
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Electrophoresis, Polyacrylamide Gel
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Esterases / metabolism*
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Gammainfluenzavirus / metabolism*
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Gammainfluenzavirus / physiology
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Hemagglutinins, Viral / metabolism*
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Immunoprecipitation
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Temperature*
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Viral Fusion Proteins / metabolism*
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Virus Replication / physiology
Substances
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Hemagglutinins, Viral
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Viral Fusion Proteins
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Esterases