Asymmetric synthesis of cyclopropanes with a monofluorinated quaternary stereocenter

Org Lett. 2012 Oct 5;14(19):5130-3. doi: 10.1021/ol3024264. Epub 2012 Sep 27.

Abstract

New chiral fluorinated reagents (N-(dibromofluoroacetyl)oxazolidinones) were easily synthesized and used in an asymmetric cyclopropanation process. The Michael initiated ring closure reaction provided chiral cyclopropanes bearing a fluorinated quaternary stereocenter. Various electron-deficient alkenes can be used to efficiently obtain chiral polysubtituted fluorinated cyclopropanes in good yields. Moderate to very good cis/trans ratios were obtained with a high level of diastereoselectivity for each isomer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclopropanes / chemical synthesis*
  • Fluorine / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Oxazolidinones / chemistry
  • Stereoisomerism

Substances

  • Cyclopropanes
  • Oxazolidinones
  • Fluorine