Identifying the intermolecular hydrogen-bonding supramolecular synthons in an indomethacin-nicotinamide cocrystal by solid-state NMR

Chem Commun (Camb). 2012 Nov 14;48(88):10844-6. doi: 10.1039/c2cc36094b. Epub 2012 Oct 1.

Abstract

Two-dimensional (1)H double-quantum and (14)N-(1)H & (1)H-(13)C heteronuclear magic-angle spinning (MAS) NMR spectra recorded at natural isotopic abundance identify specific intermolecular COOH···N(arom) and CH(arom)···O=C hydrogen-bonding interactions in the solid-state structure of an indomethacin-nicotinamide cocrystal, thus additionally proving cocrystal formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallization
  • Hydrogen Bonding
  • Indomethacin / chemistry*
  • Magnetic Resonance Spectroscopy / methods
  • Niacinamide / chemistry*

Substances

  • Niacinamide
  • Indomethacin