We theoretically demonstrate the possibility of observing the macroscopic Zeno effect for nonlinear waveguides with localized dissipation. We show the existence of stable stationary flows, which are balanced by losses in the dissipative domain. The macroscopic Zeno effect manifests itself in the nonmonotonic dependence of the stationary flow on the strength of the dissipation. In particular, we highlight the importance of the dissipation parameters in observing the phenomenon. Our results are applicable to a large variety of systems, including the condensates of atoms or quasiparticles and optical waveguides.