Complete cDNA sequence and chromosomal localization of mouse alpha 1-antitrypsin

Genomics. 1990 Jan;6(1):100-4. doi: 10.1016/0888-7543(90)90453-2.

Abstract

A cDNA encoding the complete open reading frame of murine alpha 1-antitrypsin has been cloned and sequenced. The nucleic acid and predicted amino acid sequences show homology to human alpha 1-antitrypsin and demonstrate the preservation of critical structural determinants for intracellular targeting, carbohydrate attachment, and catalytic function. The alpha 1-antitrypsin gene locus (Aat) has been localized on murine chromosome 12E----F by in situ hybridization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Chromosome Mapping
  • Cloning, Molecular
  • Humans
  • Mice
  • Molecular Sequence Data
  • Sequence Homology, Nucleic Acid
  • alpha 1-Antitrypsin / genetics*

Substances

  • alpha 1-Antitrypsin

Associated data

  • GENBANK/M25529