Neurophysiological studies in nonhuman species indicated that neurons in the superior colliculus (SC) are involved in the control of upper limb movements. These findings suggested that the SC represents a crucial hub in a general sensorimotor network, including skeletomotor as much as oculomotor functions. In contrast to the SC in the various animal models, the human SC is largely unknown territory. In particular, it is unknown whether findings of reach-related activity in the nonhuman SC can be extrapolated to humans. Using fMRI we found signal increases at superficial/intermediate and deep locations at the SC during the execution of arm movements. In contrast, signals related to saccade execution were confined to the superficial and intermediate locations. Although targets for reaching were presented in the left and right hemifields under central fixation, we found a lateralization of reach-related signals with respect to the active arm. In contrast, saccade-related activity was bilateral, in agreement with the bilateral target presentation and the resulting directions of saccades. Our results suggest that the human SC not only contributes to the coordination of eye movements and spatial shifts of attentions but also to the sensorimotor control of arm movements.