The rs42524 COL1A2 polymorphism is associated with primary intracerebral hemorrhage in a Chinese population

Hypertensive arteriosclerosis and amyloid angiopathy account for 78-88% of primary cerebral hemorrhages, and collagen plays a critical role in the pathology of these hemorrhages. The COL1A2 gene on chromosome 7q22.1 has been shown to be associated with intracranial aneurysms. In our study, 393 Han Chinese patients with primary intracerebral hemorrhage (mean age 58.49 ± 9.49 years) and 486 controls (mean age 59.22 ± 8.79 years) underwent genotyping for the rs42524 polymorphism of COL1A2 using polymerase chain reaction-based restriction analysis. Differences in genotypic and allelic frequencies between the cases and controls were evaluated using the χ(2) test. The association between the rs42524 polymorphism and primary intracerebral hemorrhage was also tested using logistic regression analysis with adjustment for risk factors. We found that there was a significant difference between patients with primary intracerebral hemorrhage and control subjects with respect to genotype distribution (χ(2)=16.33, P<0.001) and allelic frequencies (χ(2)=15.01; P<0.001; odds ratio 2.261; 95% confidence interval 1.482-3.451) for the rs42524 polymorphism of COL1A2. Adjustment for risk factors did not change our conclusions. We conclude that the COL1A2 rs42524 polymorphism could be a genetic risk factor for primary intracerebral hemorrhage among Han Chinese.