pH-responsive size-tunable self-assembled DNA dendrimers

Tao Zhou; Ping Chen; Lin Niu; Juan Jin; Dehai Liang; Zhibo Li; Zhongqiang Yang; Dongsheng Liu

doi:10.1002/anie.201205862

pH-responsive size-tunable self-assembled DNA dendrimers

Angew Chem Int Ed Engl. 2012 Nov 5;51(45):11271-4. doi: 10.1002/anie.201205862. Epub 2012 Oct 4.

Authors

Tao Zhou¹, Ping Chen, Lin Niu, Juan Jin, Dehai Liang, Zhibo Li, Zhongqiang Yang, Dongsheng Liu

Affiliation

¹ Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China.

PMID: 23037637
DOI: 10.1002/anie.201205862

Abstract

Putting the DNA in dendrimers: a strategy to swiftly prepare DNA dendrimers based solely on DNA self-assembly is presented. This technique produces highly pure DNA dendrimers with an excellent yield of high generation dendrimers. The incorporation of molecular motors (i-motifs) into the DNA dendrimers allows for a change in size (up to 30%) in response to changing pH values.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Circular Dichroism
DNA / chemical synthesis
DNA / chemistry*
Dendrimers / chemical synthesis
Dendrimers / chemistry*
Electrophoresis, Agar Gel
Hydrogen-Ion Concentration
Light
Molecular Sequence Data
Nucleic Acid Conformation
Scattering, Radiation

Substances

Dendrimers
DNA