Sexual transmission of predicted CXCR4-tropic HIV-1 likely originating from the source partner's seminal cells

Virology. 2012 Dec 5;434(1):2-4. doi: 10.1016/j.virol.2012.09.010. Epub 2012 Oct 3.

Abstract

We present a case of sexual transmission of HIV-1 predicted to have CXCR4-tropism during male-to-male sexual exposure. Phylogenetic analyses exclude cell-free virus in the seminal plasma of the source partner and possibly point to the seminal cells as the origin of the transmission event.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cluster Analysis
  • HIV Infections / transmission*
  • HIV-1 / genetics
  • HIV-1 / isolation & purification*
  • HIV-1 / pathogenicity*
  • Humans
  • Male
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Viral / genetics*
  • Receptors, CXCR4 / metabolism
  • Receptors, HIV / metabolism
  • Semen / virology*
  • Sequence Analysis, DNA
  • Young Adult

Substances

  • CXCR4 protein, human
  • RNA, Viral
  • Receptors, CXCR4
  • Receptors, HIV