Empirical evidence for psychopharmacologic treatment in early-onset psychosis and schizophrenia

Child Adolesc Psychiatr Clin N Am. 2012 Oct;21(4):885-909. doi: 10.1016/j.chc.2012.07.011.

Abstract

Psychotic symptoms presenting in youth can be clinically complex and require that a child and adolescent psychiatrist use significant skill in making a diagnosis and initiating treatment. There are a number of illnesses to rule out before making a diagnosis of early-onset schizophrenia in particular. Psychosis in youth has significant associated morbidity and places high demands not only on families but also on the medical and educational systems. More effective pharmacologic and nonpharmacologic treatments for psychosis are needed. Nonpharmacologic therapies targeting relatively treatment-resistant domains of dysfunction such as neurocognition are also necessary as adjunctive treatments to our extant pharmacologic agents.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Age of Onset
  • Antipsychotic Agents / administration & dosage*
  • Antipsychotic Agents / adverse effects
  • Child
  • Clinical Trials as Topic
  • Humans
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / drug therapy*
  • Schizophrenia / diagnosis
  • Schizophrenia / drug therapy*

Substances

  • Antipsychotic Agents