Abstract
Prevalence rates of hepatocellular carcinoma (HCC)-associated hepatitis B virus (HBV) pre-S mutants among most genotypes are still lacking. In this study, viral (sub)genotypes of 70 Argentine nucleotide sequences (33 newly obtained) were determined by phylogenetic analysis, and the presence of such mutants was assessed in the American continent for the first time. Nucleotide substitutions of the pre-S2 start codon were observed in 10% of the HBV/A2 sequences. Ten per cent of the HBV/A2 and 12.5% of the HBV/F1b - but none of HBV/F4 - exhibited a deletion in the pre-S1/pre-S2 region. The contribution of these variants to liver cirrhosis (LC) and/or HCC development among HBV/F and HBV/A isolates deserves further prospective clinical studies.
© 2012 Blackwell Publishing Ltd.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Amino Acid Sequence
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Argentina
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Carcinoma, Hepatocellular / complications
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Carcinoma, Hepatocellular / virology*
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DNA, Viral / genetics
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Female
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Genotype
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Hepatitis B / complications
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Hepatitis B / virology*
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Hepatitis B Surface Antigens / chemistry
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Hepatitis B Surface Antigens / genetics*
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Hepatitis B virus / classification
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Hepatitis B virus / genetics*
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Hepatitis B virus / isolation & purification
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Humans
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Liver Neoplasms / complications
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Liver Neoplasms / virology*
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Male
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Middle Aged
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Mutation
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Prospective Studies
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Protein Precursors / chemistry
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Protein Precursors / genetics*
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Sequence Deletion
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Young Adult
Substances
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DNA, Viral
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Hepatitis B Surface Antigens
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Protein Precursors
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presurface protein 1, hepatitis B surface antigen