Convergent extension: using collective cell migration and cell intercalation to shape embryos

Development. 2012 Nov;139(21):3897-904. doi: 10.1242/dev.073007.

Abstract

Body axis elongation represents a common and fundamental morphogenetic process in development. A key mechanism triggering body axis elongation without additional growth is convergent extension (CE), whereby a tissue undergoes simultaneous narrowing and extension. Both collective cell migration and cell intercalation are thought to drive CE and are used to different degrees in various species as they elongate their body axis. Here, we provide an overview of CE as a general strategy for body axis elongation and discuss conserved and divergent mechanisms underlying CE among different species.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Body Patterning / genetics
  • Body Patterning / physiology*
  • Cell Differentiation / genetics
  • Cell Differentiation / physiology
  • Cell Movement / genetics
  • Cell Movement / physiology*
  • Cell Polarity / genetics
  • Cell Polarity / physiology
  • Humans
  • Xenopus laevis
  • Zebrafish