Lethal intratumoral haemorrhages of brain metastases during radiosurgery: case reports and literature review

M A A Salek; B Karlsson; T T Yeo; P Hanssens; C Ning

doi:10.1007/s00701-012-1507-x

Lethal intratumoral haemorrhages of brain metastases during radiosurgery: case reports and literature review

Acta Neurochir (Wien). 2013 Jan;155(1):115-8. doi: 10.1007/s00701-012-1507-x. Epub 2012 Sep 30.

Authors

M A A Salek¹, B Karlsson, T T Yeo, P Hanssens, C Ning

Affiliation

¹ Division of Neurosurgery, Department of Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 110974, Singapore. [email protected]

PMID: 23053282
DOI: 10.1007/s00701-012-1507-x

Abstract

Gamma Knife surgery (GKS) is an effective and important treatment modality in the management of brain metastases. The short-term complication rate is low and the tumour control rate high. Complications caused by acute radiation-induced oedema are rare and usually benign. In this article, two cases of lethal haemorrhagic event immediately following GKS are described from two centres, which had prompted us to review the literature.

Publication types

Case Reports
Review

MeSH terms

Aged
Brain Neoplasms / mortality
Brain Neoplasms / secondary*
Brain Neoplasms / surgery*
Carcinoma, Non-Small-Cell Lung / mortality
Carcinoma, Non-Small-Cell Lung / secondary*
Carcinoma, Non-Small-Cell Lung / surgery*
Fatal Outcome
Female
Humans
Intracranial Hemorrhages / etiology*
Intracranial Hemorrhages / mortality
Lung Neoplasms / mortality
Lung Neoplasms / pathology
Lung Neoplasms / therapy
Male
Middle Aged
Radiosurgery / adverse effects*