Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles

Adv Mater. 2013 Jan 11;25(2):227-32. doi: 10.1002/adma.201202932. Epub 2012 Oct 11.

Abstract

DNA-containing micellar nanoparticles with distinctly different and highly uniform morphologies are prepared via condensation of plasmid DNA with a block copolymer of polyethylene glycol and a polycation in solvents of different polarity. Molecular dynamics simulations explain the underlying mechanism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amides / chemistry
  • DNA / chemistry*
  • Dimethylformamide / chemistry
  • Micelles
  • Nanoparticles / chemistry*
  • Phosphoric Acids / chemistry
  • Plasmids / chemistry*
  • Polyethylene Glycols / chemistry
  • Polymers / chemistry*
  • Water / chemistry

Substances

  • Amides
  • Micelles
  • Phosphoric Acids
  • Polymers
  • Water
  • Polyethylene Glycols
  • Dimethylformamide
  • DNA
  • phosphoramidic acid