Glia: regulating synaptogenesis from multiple directions

Allison Rosen Bialas; Beth Stevens

doi:10.1016/j.cub.2012.08.036

Glia: regulating synaptogenesis from multiple directions

Curr Biol. 2012 Oct 9;22(19):R833-5. doi: 10.1016/j.cub.2012.08.036.

Authors

Allison Rosen Bialas¹, Beth Stevens

Affiliation

¹ Department of Neurobiology and Department of Neurology, F.M. Kirby Neurobiology Center, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

PMID: 23058800
DOI: 10.1016/j.cub.2012.08.036

Abstract

Glia cells are uniquely positioned at synapses, contacting pre- and post-synaptic terminals. At the Drosophila neuromuscular junction, a novel glia-derived TGF-β ligand has been found that modulates a retrograde synaptogenic signal.

Publication types

Comment

MeSH terms

Animals
Drosophila / metabolism*
Drosophila Proteins / metabolism*
Neuroglia / metabolism*
Neuromuscular Junction / growth & development*
Synapses / physiology*
Transforming Growth Factor beta / metabolism*

Substances

Drosophila Proteins
Transforming Growth Factor beta
gbb protein, Drosophila
mav protein, Drosophila