Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects

Michael J Colditz; Karin van Leyen; Rosalind L Jeffree

doi:10.1016/j.jocn.2012.03.013

Aminolevulinic acid (ALA)-protoporphyrin IX fluorescence guided tumour resection. Part 2: theoretical, biochemical and practical aspects

J Clin Neurosci. 2012 Dec;19(12):1611-6. doi: 10.1016/j.jocn.2012.03.013. Epub 2012 Oct 9.

Authors

Michael J Colditz¹, Karin van Leyen, Rosalind L Jeffree

Affiliation

¹ Kenneth G. Jamieson Department of Neurosurgery, Royal Brisbane & Women's Hospital, Herston, Queensland 4029, Australia.

PMID: 23059058
DOI: 10.1016/j.jocn.2012.03.013

Abstract

The importance of the extent of resection for gliomas, and the utility of aminolevulinic acid (ALA) and protoporphyrin IX fluorescence in increasing the extent of resection, has become increasingly evident over the past decade. This review continues from Part 1 and focuses on the biochemical mechanisms by which ALA ingestion leads to tumour fluorescence, and discusses practicalities of the equipment and techniques needed to introduce ALA and fluorescence guided resection into neurosurgical practice.

Publication types

Review

MeSH terms

Aminolevulinic Acid* / pharmacology
Brain Neoplasms / surgery*
Fluorescent Dyes* / pharmacology
Glioma / surgery*
Humans
Neurosurgical Procedures / methods
Photosensitizing Agents / pharmacology
Protoporphyrins* / pharmacology
Surgery, Computer-Assisted / methods

Substances

Fluorescent Dyes
Photosensitizing Agents
Protoporphyrins
Aminolevulinic Acid
protoporphyrin IX