Q141K polymorphism of ABCG2 protein is associated with poor prognosis in adult acute myeloid leukemia treated with idarubicin-based chemotherapy

Haematologica. 2013 Mar;98(3):e28-9. doi: 10.3324/haematol.2012.075895. Epub 2012 Oct 12.
No abstract available

Publication types

  • Letter

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters / genetics*
  • Adult
  • Aged
  • Aged, 80 and over
  • Amino Acid Substitution
  • Antibiotics, Antineoplastic / therapeutic use
  • Humans
  • Idarubicin / therapeutic use
  • Leukemia, Myeloid, Acute / drug therapy
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / mortality*
  • Middle Aged
  • Neoplasm Proteins / genetics*
  • Polymorphism, Single Nucleotide*
  • Prognosis
  • Young Adult

Substances

  • ABCG2 protein, human
  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • ATP-Binding Cassette Transporters
  • Antibiotics, Antineoplastic
  • Neoplasm Proteins
  • Idarubicin