Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency

Maria Candela Iglesias; Olivia Briceno; Emma Gostick; Arnaud Moris; Céline Meaudre; David A Price; Marie-Noëlle Ungeheuer; Asier Saez-Cirion; Roberto Mallone; Victor Appay

doi:10.1016/j.imlet.2012.10.002

Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency

Immunol Lett. 2013 Jan;149(1-2):119-22. doi: 10.1016/j.imlet.2012.10.002. Epub 2012 Oct 13.

Authors

Maria Candela Iglesias¹, Olivia Briceno, Emma Gostick, Arnaud Moris, Céline Meaudre, David A Price, Marie-Noëlle Ungeheuer, Asier Saez-Cirion, Roberto Mallone, Victor Appay

Affiliation

¹ INSERM UMR S 945, Infections and Immunity, Université Pierre et Marie Curie-Paris 6, Hôpital Pitié-Salpêtrière, Paris, France.

PMID: 23068784
DOI: 10.1016/j.imlet.2012.10.002

Abstract

The factors that determine the immunodominance, efficacy and almost ubiquitous presence of CD8(+) T-cell responses to the HLA-B27-restricted HIV-1 p24 Gag-derived KK10 epitope remain to be fully elucidated. Here, we show that neither the precursor frequency nor the priming capacity of KK10-reactive CD8(+) T-cells within the naïve pool differ substantially in comparison to other specificities. These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

CD8-Positive T-Lymphocytes / immunology*
Epitopes, T-Lymphocyte / immunology*
Female
HIV Core Protein p24 / immunology*
HIV-1 / immunology*
HLA-B27 Antigen / immunology*
Humans
Male

Substances

Epitopes, T-Lymphocyte
HIV Core Protein p24
HLA-B27 Antigen
p24 protein, Human Immunodeficiency Virus Type 1