Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines

Phytochemistry. 2013 Feb:86:208-17. doi: 10.1016/j.phytochem.2012.09.003. Epub 2012 Oct 15.

Abstract

Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Aporphines / chemistry
  • Aporphines / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Diterpenes / chemistry
  • Diterpenes / pharmacology
  • Drug Resistance, Neoplasm
  • Euphorbia / chemistry*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Quinolines / chemistry
  • Quinolines / pharmacology

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents
  • Aporphines
  • Diterpenes
  • Quinolines
  • aporphine
  • tariquidar