Insights into tuberculosis from the zebrafish model

Russell D Berg; Lalita Ramakrishnan

doi:10.1016/j.molmed.2012.10.002

Insights into tuberculosis from the zebrafish model

Trends Mol Med. 2012 Dec;18(12):689-90. doi: 10.1016/j.molmed.2012.10.002. Epub 2012 Oct 17.

Authors

Russell D Berg¹, Lalita Ramakrishnan

Affiliation

¹ Department of Molecular and Cell Biology, University of Washington, Seattle, WA 98195, USA.

PMID: 23084762
DOI: 10.1016/j.molmed.2012.10.002

Abstract

Mycobacterium tuberculosis (MTB) continues to plague humanity because of significant gaps in our understanding of MTB infection, including the nature of a protective versus pathological host response, why antimicrobial cure is so difficult, and the ineffectiveness of vaccination. The development of a zebrafish model, utilizing infection with the natural fish pathogen Mycobacterium marinum (Mm), has yielded important insights into tuberculosis with immediate clinical applications.

MeSH terms

Animals
Disease Models, Animal*
Granuloma / pathology
Mycobacterium marinum*
Tuberculosis / physiopathology*
Zebrafish*

Abstract

MeSH terms

Grants and funding