Background: Fast analysis of chemicals in samples of complex mixtures is important for many analytical applications including therapeutic drug monitoring and food safety screening.
Methods: Based on the paper spray technology developed recently, a high throughput device was developed in this work and used for evaluation of the fast quantitative analysis using paper spray mass spectrometry.
Results: The performance of the method was characterized with bovine blood samples spiked with sunitinib and nicotine. At optimized condition, relatively fast analysis speed of 7s/sample was achieved with relatively good LOQs (1 ng/ml) and quantitation.
Conclusion: In an application of the method for food screening, LODs better than 1 ng/g were achieved for clenbuterol in beef.
Copyright © 2012 Elsevier B.V. All rights reserved.