Abstract
Phytochemical investigation of the stem of Morus notabilis led to the isolation and characterization of 10 compounds of 2-arylbenzofurans (1-10), including two new compounds, (2'R)-2',3'-dihydro-2'-(1-hydroxy-1-methylethyl)-2,6'-bibenzofuran-6,4'-diol (1) and 5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran (2). Moracins O (6) and P (10) showed inhibitory effects on mushroom tyrosinase with IC₅₀ values being lower than that of kojic acid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricales / enzymology
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Inhibitory Concentration 50
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Molecular Structure
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Monophenol Monooxygenase / antagonists & inhibitors*
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Morus / chemistry*
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Nuclear Magnetic Resonance, Biomolecular
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Plant Stems / chemistry
Substances
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(2'R)-2',3'-dihydro-2'-(1-hydroxy-1-methylethyl)-2,6'-bibenzofuran-6,4'-diol
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5,6-dimethoxy-2-(3-hydroxy-5-methoxyphenyl)benzofuran
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Benzofurans
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Drugs, Chinese Herbal
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Monophenol Monooxygenase