Abstract
The efficacy of daptomycin, imipenem, or rifampin with fosfomycin was evaluated and compared with that of daptomycin-rifampin in a tissue cage model infection caused by methicillin-resistant Staphylococcus aureus (MRSA). Strain HUSA 304 was used. The study yielded the following results for MICs (in μg/ml): fosfomycin, 4; daptomycin, 1; imipenem, 0.25; and rifampin, 0.03. The study yielded the following results for minimum bactericidal concentration (MBC) (in μg/ml): fosfomycin, 8; daptomycin, 4; imipenem, 32; and rifampin, 0.5. Daptomycin-rifampin was confirmed as the most effective therapy against MRSA foreign-body infections. Fosfomycin combinations with high doses of daptomycin and rifampin were efficacious alternative therapies in this setting. Fosfomycin-imipenem was relatively ineffective and did not protect against resistance.
MeSH terms
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Animals
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Anti-Bacterial Agents / blood
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Anti-Bacterial Agents / pharmacokinetics
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Anti-Bacterial Agents / pharmacology*
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Colony Count, Microbial
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Daptomycin / blood
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Daptomycin / pharmacokinetics
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Daptomycin / pharmacology*
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Disease Models, Animal
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Drug Combinations
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Drug Resistance, Bacterial
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Foreign-Body Reaction / blood
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Foreign-Body Reaction / drug therapy*
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Foreign-Body Reaction / microbiology
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Fosfomycin / blood
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Fosfomycin / pharmacokinetics
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Fosfomycin / pharmacology*
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Imipenem / blood
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Imipenem / pharmacokinetics
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Imipenem / pharmacology*
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Methicillin-Resistant Staphylococcus aureus / drug effects*
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Methicillin-Resistant Staphylococcus aureus / growth & development
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Microbial Sensitivity Tests
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Rats
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Rats, Wistar
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Rifampin / blood
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Rifampin / pharmacokinetics
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Rifampin / pharmacology*
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Staphylococcal Infections / blood
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / microbiology
Substances
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Anti-Bacterial Agents
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Drug Combinations
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Fosfomycin
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Imipenem
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Daptomycin
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Rifampin