Abstract
Background/aims:
The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC).
Methods:
98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies and without TCR) were studied.
Results:
The HLA-B35 was significantly increased in TRC group (p=0.0038).
Conclusion:
The presence of HLA-B35 may simultaneously predispose to progression to AIDS and TRC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acquired Immunodeficiency Syndrome / blood*
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Acquired Immunodeficiency Syndrome / complications
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Acquired Immunodeficiency Syndrome / genetics
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Adult
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Alleles*
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Biomarkers / blood
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Case-Control Studies
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Chorioretinitis / blood*
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Chorioretinitis / complications
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Chorioretinitis / genetics
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Disease Progression
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Female
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Genetic Predisposition to Disease
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HLA-B35 Antigen / blood*
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Humans
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Male
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Middle Aged
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Toxoplasmosis, Ocular / blood*
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Toxoplasmosis, Ocular / complications
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Toxoplasmosis, Ocular / genetics
Substances
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Biomarkers
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HLA-B35 Antigen