CuAAC click functionalization of azide-modified nanodiamond with a photoactivatable CO-releasing molecule (PhotoCORM) based on [Mn(CO)3(tpm)]+

Chem Commun (Camb). 2012 Dec 7;48(94):11528-30. doi: 10.1039/c2cc36491c.

Abstract

The copper-catalyzed 1,3-dipolar azide-alkyne cycloaddition (CuAAC) was used for the first time to attach a biologically active carbon monoxide delivery agent to modified nanodiamond (ND) as a highly biocompatible carrier. The [Mn(CO)(3)(tpm)](+) photoactivatable CO-releasing molecule (PhotoCORM) on the surface retained the carbon monoxide release properties of the parent compound as shown with the myoglobin assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Azides / chemistry*
  • Carbon Monoxide / chemistry*
  • Catalysis
  • Click Chemistry*
  • Copper / chemistry*
  • Cycloaddition Reaction
  • Nanodiamonds / chemistry*
  • Organometallic Compounds / chemistry*
  • Photochemical Processes
  • Pyrazoles / chemistry

Substances

  • Alkynes
  • Azides
  • Nanodiamonds
  • Organometallic Compounds
  • Pyrazoles
  • Copper
  • Carbon Monoxide