Adsorption of multimeric T cell antigens on carbon nanotubes: effect on protein structure and antigen-specific T cell stimulation

Small. 2013 Mar 11;9(5):666-72. doi: 10.1002/smll.201201684. Epub 2012 Oct 23.

Abstract

Antigen-specific activation of cytotoxic T cells can be enhanced up to three-fold more than soluble controls when using functionalized bundled carbon nanotube substrates ((b) CNTs). To overcome the denaturing effects of direct adsorption on (b) CNTs, a simple but robust method is demonstrated to stabilize the T cell stimulus on carbon nanotube substrates through non-covalent attachment of the linker neutravidin.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adsorption
  • Animals
  • Antigens / chemistry*
  • Biomimetics / methods
  • Circular Dichroism
  • Mice
  • Nanotubes, Carbon / chemistry*
  • T-Lymphocytes / immunology*

Substances

  • Antigens
  • Nanotubes, Carbon