Abstract
Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cyclohexenes / chemistry
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Cyclohexenes / isolation & purification*
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Cyclohexenes / pharmacology*
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pancreatic Neoplasms / drug therapy
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Plant Stems / chemistry
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Thailand
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Uvaria / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Cyclohexenes