Severe psoriasis with positive tuberculosis test and treatment with biologic therapy: a case report

Nevena Skroza; Ilaria Proietti; Nicoletta Bernardini; Giorgio La Viola; Francesca Nicolucci; Ersilia Tolino; Sara Zuber; Concetta Potenza

Severe psoriasis with positive tuberculosis test and treatment with biologic therapy: a case report

Cutis. 2012 Sep;90(3):120-2.

Authors

Nevena Skroza¹, Ilaria Proietti, Nicoletta Bernardini, Giorgio La Viola, Francesca Nicolucci, Ersilia Tolino, Sara Zuber, Concetta Potenza

Affiliation

¹ Department of Dermatology "Daniele Innocenzi," Sapienza University of Rome, Polo Pontino, Italy.

PMID: 23094309

Abstract

Psoriasis and tuberculosis (TB) are 2 conditions with high prevalence in the general population, often present simultaneously in the same patient. The crucial cytokine involved in the pathogenesis of psoriasis, tumor necrosis factor alpha (TNF-alpha), also is important in defending against mycobacteria. Therefore, it is important to screen patients for a latent TB infection (LTBI) while they are undergoing treatment with TNF-alpha antagonists. We present a case of a patient with psoriasis and LTBI who underwent treatment with etanercept.

Publication types

Case Reports

MeSH terms

Etanercept
Humans
Immunoglobulin G / pharmacology
Immunoglobulin G / therapeutic use
Immunologic Factors / pharmacology
Immunologic Factors / therapeutic use
Latent Tuberculosis / diagnosis*
Male
Mass Screening / methods
Middle Aged
Psoriasis / drug therapy*
Psoriasis / pathology
Receptors, Tumor Necrosis Factor / therapeutic use
Severity of Illness Index
Tuberculin Test
Tumor Necrosis Factor-alpha / antagonists & inhibitors*
Tumor Necrosis Factor-alpha / metabolism

Substances

Immunoglobulin G
Immunologic Factors
Receptors, Tumor Necrosis Factor
Tumor Necrosis Factor-alpha
Etanercept