Indicators of benzodiazepine use in nursing home residents in France: a cross-sectional study

J Am Med Dir Assoc. 2013 Jan;14(1):29-33. doi: 10.1016/j.jamda.2012.09.002. Epub 2012 Oct 23.

Abstract

Objectives: Little information is available about associations between nursing home (NH) structural and organizational aspects and benzodiazepine prescriptions, particularly for long-acting drugs. This study addressed this knowledge gap.

Design: Cross-sectional study.

Setting: One hundred seventy-five NHs from France.

Participants: A total of 6275 NH residents, aged 86 years (± 8.2), and mostly women (73.7%).

Measurements: Outcome measures were: (1) benzodiazepine and (2) long-acting benzodiazepine use. NH staff sent to research team all drug prescriptions in the week participants were included in the study; staff also recorded information on residents' characteristics, and NHs structure and internal organization. Binary logistic regressions were performed separately on total and long-acting benzodiazepine.

Results: A total of 3350 persons took benzodiazepine; 577 took long-acting benzodiazepine. Subject-related characteristics were the main correlates of benzodiazepine use. NH characteristics were also related to this outcome: number of beds ≥ 91 (Odds Ratio (OR) 0.820, 95% Confidence Interval (CI) 0.682-0.986), special care unit (OR 1.131, 95% CI 1.000-1.279), pharmacy for internal usage (OR 1.341, 95%CI 1.128-1.594), and date records of the first prescription of psychotropics (OR 1.394, 95% CI 1.209-1.607). Pharmacy for internal usage was also associated with long-acting benzodiazepine (OR 1.374, 95% CI 1.076-1.754).

Conclusions: NH structure- and organization-related indicators impact benzodiazepine use among NH residents. This finding is of particular importance because these indicators are more easily modifiable than subject-related characteristics. Therefore, NH directors and medical staff should be aware about this to implement feasible modifications for reducing inappropriate and chronic benzodiazepine use.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Aged, 80 and over
  • Benzodiazepines / therapeutic use*
  • Chi-Square Distribution
  • Cross-Sectional Studies
  • Disability Evaluation
  • Female
  • France
  • Humans
  • Inappropriate Prescribing
  • Logistic Models
  • Male
  • Nursing Homes*
  • Polypharmacy
  • Practice Patterns, Physicians' / statistics & numerical data*

Substances

  • Benzodiazepines