Abstract
The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Typing Techniques / methods*
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Dysentery, Bacillary / epidemiology
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Dysentery, Bacillary / microbiology
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Global Health
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Humans
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Molecular Epidemiology / methods
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Molecular Typing / methods*
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Pandemics
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Phylogeny*
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Polymorphism, Single Nucleotide*
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Shigella sonnei / classification*
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Shigella sonnei / genetics*
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Shigella sonnei / isolation & purification
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Transition Temperature