Two novel alleles at HLA-B locus identified in two volunteer bone marrow donors by sequence-based typing

Int J Immunogenet. 2013 Aug;40(4):328-30. doi: 10.1111/iji.12011. Epub 2012 Nov 3.

Abstract

Two novel human leucocyte antigen (HLA) class I alleles have been identified in two Italian individuals. HLA-B*27:07:02 is identical to HLA-B*27:07:01 except for a nucleotide substitution at position 846 (A->G) resulting in a silent mutation. HLA-B*35:206 differs from the most similar allele, HLA-B*35:08:01, because of a single base mutation at position 149 (G->C) causing an aminoacidic change at codon 26 from Gly to Ala.

MeSH terms

  • Amino Acid Sequence
  • Amino Acid Substitution
  • Base Sequence
  • Bone Marrow
  • Bone Marrow Cells / cytology
  • Bone Marrow Transplantation
  • HLA-B27 Antigen / genetics*
  • HLA-B35 Antigen / genetics*
  • Histocompatibility Testing
  • Humans
  • Italy
  • Polymorphism, Single Nucleotide
  • Sequence Analysis, DNA

Substances

  • HLA-B*27:07 antigen
  • HLA-B27 Antigen
  • HLA-B35 Antigen