Stressed out: endogenous aldehydes damage hematopoietic stem cells

Kalindi Parmar; Alan D D'Andrea

doi:10.1016/j.stem.2012.10.007

Stressed out: endogenous aldehydes damage hematopoietic stem cells

Cell Stem Cell. 2012 Nov 2;11(5):583-4. doi: 10.1016/j.stem.2012.10.007.

Authors

Kalindi Parmar¹, Alan D D'Andrea

Affiliation

¹ Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

PMID: 23122283
DOI: 10.1016/j.stem.2012.10.007

Abstract

Despite a well-defined role for the Fanconi anemia (FA) pathway in mediating DNA repair, the mechanisms underlying the bone marrow failure in FA patients are poorly defined. Recently in Nature, Garaycoechea et al. (2012), identify aldehyde-mediated genotoxicity of hematopoietic stem cells as a cause for bone marrow failure.

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