Cyclometalated iridium(III) polypyridine dibenzocyclooctyne complexes as the first phosphorescent bioorthogonal probes

Chem Commun (Camb). 2013 May 14;49(39):4271-3. doi: 10.1039/c2cc36907a. Epub 2012 Nov 2.

Abstract

We report the synthesis, photophysical behavior, and biological properties of new cyclometalated iridium(iii) polypyridine complexes appended with a dibenzocyclooctyne (DIBO) moiety; these complexes have been utilized as the first phosphorescent bioorthogonal probes for azide-modified biomolecules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CHO Cells
  • Coordination Complexes / chemistry*
  • Cricetinae
  • Cricetulus
  • Fluorescent Dyes / chemistry*
  • Iridium / chemistry*
  • Microscopy, Confocal
  • Pyridines / chemistry*

Substances

  • Coordination Complexes
  • Fluorescent Dyes
  • Pyridines
  • Iridium
  • pyridine