A novel small molecule facilitates the reprogramming of human somatic cells into a pluripotent state and supports the maintenance of an undifferentiated state of human pluripotent stem cells

Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12509-13. doi: 10.1002/anie.201206691. Epub 2012 Nov 4.

Abstract

Booster of pluripotency: RSC133, a new synthetic derivative of indoleacrylic acid/indolepropionic acid, exhibits dual activity by inhibiting histone deacetylase and DNA methyltransferase. Furthermore it potently improves the reprogramming of human somatic cells into a pluripotent state and aids the growth and maintenance of human pluripotent stem cells (hPSCs).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation / drug effects
  • Cell Line
  • Cell Proliferation / drug effects
  • Cellular Reprogramming / drug effects
  • DNA (Cytosine-5-)-Methyltransferases / antagonists & inhibitors
  • DNA (Cytosine-5-)-Methyltransferases / metabolism
  • Histone Deacetylases / chemistry
  • Histone Deacetylases / metabolism
  • Humans
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Mice
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / enzymology
  • Pluripotent Stem Cells / metabolism
  • Transcription Factors / metabolism

Substances

  • Indoles
  • RSC133
  • Transcription Factors
  • indolepropionic acid
  • indoleacrylic acid
  • DNA (Cytosine-5-)-Methyltransferases
  • Histone Deacetylases