Abstract
We report here the synthesis of heparin-polynitroxide derivatives (HPNs) in which nitroxide moieties are linked either to uronic acid or glycosamine residues of the heparin macromolecule. HPNs have low anticoagulant activity, possess superoxide scavenging properties, bind to the vascular endothelium/extra-cellular matrix and can be detected by EPR and MRI techniques. As the vascular wall-targeted redox-active paramagnetic compounds, HPNs may have both diagnostic (molecular MRI) and therapeutic (ecSOD mimics) applications.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anticoagulants / blood
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Anticoagulants / chemistry
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Anticoagulants / metabolism
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Anticoagulants / pharmacology
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Antioxidants / chemistry
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Antioxidants / metabolism*
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Electron Spin Resonance Spectroscopy
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Endothelium, Vascular / chemistry
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Endothelium, Vascular / metabolism
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Extracellular Matrix / chemistry
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Extracellular Matrix / metabolism
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Factor Xa / metabolism
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Factor Xa Inhibitors
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Heparin / chemistry
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Heparin / metabolism
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Hexosamines / chemistry
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Humans
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Magnetic Resonance Imaging*
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Molecular Probes / chemistry
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Molecular Probes / metabolism*
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Nitrogen Oxides / chemistry
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Nitrogen Oxides / metabolism
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Partial Thromboplastin Time
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Superoxides / chemistry
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Superoxides / metabolism
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Uronic Acids / chemistry
Substances
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Anticoagulants
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Antioxidants
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Factor Xa Inhibitors
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Hexosamines
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Molecular Probes
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Nitrogen Oxides
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Uronic Acids
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Superoxides
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Heparin
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Factor Xa