Abstract
A variety of functionalities were introduced at 2-aroylquinoline's C5 position, which is considered equivalent to C-3' of the B-ring of CA4, via Suzuki arylation, Sonogashira ethynylation, and Rosenmund-von Braun cyanation. These substitutions are rarely utilized in the modification of 3'-OH of CA4. The resulting products 6 and 7 having cyano and ethynyl groups exhibited comparable antiproliferative and tubulin inhibitory activities to colchicine.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetylene / chemistry*
-
Antineoplastic Agents / chemical synthesis*
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology
-
Cell Line, Tumor
-
Cell Proliferation / drug effects
-
Chemistry Techniques, Synthetic / methods*
-
Colchicine / pharmacology
-
Cyanates / chemistry*
-
Drug Resistance, Neoplasm
-
Humans
-
Molecular Structure
-
Quinolines / chemical synthesis*
-
Quinolines / chemistry
-
Quinolines / pharmacology
-
Tubulin Modulators / chemical synthesis*
-
Tubulin Modulators / chemistry
-
Tubulin Modulators / pharmacology
Substances
-
Antineoplastic Agents
-
Cyanates
-
Quinolines
-
Tubulin Modulators
-
Acetylene
-
Colchicine