Abstract
In the liver ischemia-reperfusion model, the lipid peroxide level increased during ischemic periods, while a greater increase was observed during reflow periods. The increase in the cytochrome b5 content was observed during ischemia and reflow periods. On the contrary, the cytochrome P-450 content remained unchanged during ischemic periods, but decreased during reflow periods. Bifemelane suppressed the elevation of the lipid peroxide level, the cytochrome b5 content and the decrease in cytochrome P-450 content during the period of reperfusion.
MeSH terms
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Animals
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Benzhydryl Compounds / therapeutic use*
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Cytochrome P-450 Enzyme System / metabolism
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Cytochromes b5 / metabolism
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Ischemia / complications
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Lipid Peroxides / metabolism
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Liver / injuries*
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Liver / metabolism
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Liver / pathology
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Liver Circulation / drug effects
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Male
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Malondialdehyde / metabolism
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Microsomes, Liver / drug effects
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Microsomes, Liver / enzymology
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Rats
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Rats, Inbred Strains
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Reperfusion Injury / drug therapy*
Substances
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Benzhydryl Compounds
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Lipid Peroxides
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Malondialdehyde
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Cytochromes b5
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Cytochrome P-450 Enzyme System
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bifemelane