Abstract
A retrospective case-case control study was conducted, including 60 cases with daptomycin-nonsusceptible vancomycin-resistant enterococci (DNS-VRE) matched to cases with daptomycin-susceptible VRE and to uninfected controls (1∶1∶3 ratio). Immunosuppression, presence of comorbid conditions, and prior exposure to antimicrobials were independent predictors of DNS-VRE, although prior daptomycin exposure occurred rarely. In summary, a case-case control study identified independent risk factors for the isolation of DNS-VRE: immunosuppression, multiple comorbid conditions, and prior exposures to cephalosporines and metronidazole.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / pharmacology*
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Case-Control Studies
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Cephalosporins / therapeutic use
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Comorbidity
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Daptomycin / pharmacology*
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Drug Resistance, Multiple, Bacterial*
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Enterococcus faecalis / drug effects*
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Enterococcus faecium / drug effects*
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Female
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Gram-Positive Bacterial Infections / epidemiology*
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Gram-Positive Bacterial Infections / microbiology
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Humans
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Immunosuppression Therapy
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Male
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Metronidazole / therapeutic use
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Middle Aged
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Proportional Hazards Models
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Retrospective Studies
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Risk Factors
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Statistics, Nonparametric
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Vancomycin / pharmacology*
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Vancomycin Resistance
Substances
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Anti-Bacterial Agents
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Cephalosporins
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Metronidazole
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Vancomycin
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Daptomycin