Abstract
A carbapenem-sparing regimen of tigecycline plus gentamicin or colistin was effective for treating 24 of 26 (92%) Klebsiella pneumoniae carbapenemase-producing K. pneumoniae infectious episodes in 22 polytrauma intensive care unit patients without comorbidities. The 30-day crude mortality rate was 14%. Regimens were considered appropriate in 12% of episodes according to the Vitek 2 System and in 100% based on E-test.
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / therapeutic use*
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Bacterial Proteins / metabolism*
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Carbapenems / therapeutic use
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Colistin / therapeutic use*
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Drug Therapy, Combination
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Female
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Gentamicins / therapeutic use*
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Humans
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Intensive Care Units
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Klebsiella Infections / drug therapy*
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / enzymology*
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Male
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Middle Aged
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Minocycline / analogs & derivatives*
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Minocycline / therapeutic use
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Retrospective Studies
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Tigecycline
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Treatment Outcome
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beta-Lactamases / metabolism*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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Gentamicins
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Tigecycline
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beta-Lactamases
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carbapenemase
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Minocycline
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Colistin