Two new compounds from Hicriopteris glauca and their potential antitumor activities

J Asian Nat Prod Res. 2012;14(12):1175-9. doi: 10.1080/10286020.2012.739615. Epub 2012 Nov 19.

Abstract

Chemical examination of the EtOAc extract from the stems of Hicriopteris glauca (Thunb) Ching. led to the isolation of two new compounds: lunularic acid 4'-glucoside and 2,9-dihydroxy-4,7-megastigmadiene-3-O-β-glucoside. Their structures were elucidated on the basis of spectral analysis and by comparing their spectral data with those in literature. Two compounds, along with the petroleum ether, chloroform, EtOAc, and n-BuOH extracts, were tested for cytotoxic activities. Only the n-BuOH extract showed antitumor activity against human melanoma A375 cells with IC₅₀ values of 0.80 μg/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Drug Screening Assays, Antitumor
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Ferns / chemistry*
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Extracts / chemistry
  • Plant Stems / chemistry

Substances

  • 2,9-dihydroxy-4,7-megastigmadiene-3-O-beta-glucoside
  • Antineoplastic Agents, Phytogenic
  • Drugs, Chinese Herbal
  • Glucosides
  • Plant Extracts
  • lunularic acid 4'-glucoside