Abstract
Chemical examination of the EtOAc extract from the stems of Hicriopteris glauca (Thunb) Ching. led to the isolation of two new compounds: lunularic acid 4'-glucoside and 2,9-dihydroxy-4,7-megastigmadiene-3-O-β-glucoside. Their structures were elucidated on the basis of spectral analysis and by comparing their spectral data with those in literature. Two compounds, along with the petroleum ether, chloroform, EtOAc, and n-BuOH extracts, were tested for cytotoxic activities. Only the n-BuOH extract showed antitumor activity against human melanoma A375 cells with IC₅₀ values of 0.80 μg/ml.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Ferns / chemistry*
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Extracts / chemistry
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Plant Stems / chemistry
Substances
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2,9-dihydroxy-4,7-megastigmadiene-3-O-beta-glucoside
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Glucosides
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Plant Extracts
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lunularic acid 4'-glucoside