Local autoantigen expression as essential gatekeeper of memory T-cell recruitment to islet grafts in diabetic hosts

Diabetes. 2013 Mar;62(3):905-11. doi: 10.2337/db12-0600. Epub 2012 Nov 16.

Abstract

It is generally believed that inflammatory cues can attract noncognate, "bystander" T-cell specificities to sites of inflammation. We have shown that recruitment of naive and in vitro activated autoreactive CD8⁺ T cells into endogenous islets requires local autoantigen expression. Here, we demonstrate that absence of an autoantigen in syngeneic extrapancreatic islet grafts in diabetic hosts renders the grafts "invisible" to cognate memory (and naive) T cells. We monitored the recruitment of islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)₂₀₆₋₂₁₄-reactive CD8⁺ T cells into IGRP₂₀₆₋₂₁₄-competent and IGRP₂₀₆₋₂₁₄-deficient islet grafts in diabetic wild-type or IGRP₂₀₆₋₂₁₄(-/-) nonobese diabetic hosts (harboring either naive and memory T cells or only naive IGRP₂₀₆₋₂₁₄-specific T-cells, respectively). All four host-donor combinations had development of recurrent diabetes within 2 weeks. Wild-type hosts recruited IGRP₂₀₆₋₂₁₄-specific T cells into IGRP₂₀₆₋₂₁₄(+/+) but not IGRP₂₀₆₋₂₁₄(-/-) grafts. In IGRP₂₀₆₋₂₁₄(-/-) hosts, there was no recruitment of IGRP₂₀₆₋₂₁₄-specific T cells, regardless of donor type. Graft-derived IGRP₂₀₆₋₂₁₄ activated naive IGRP₂₀₆₋₂₁₄-specific T cells, but graft destruction invariably predated their recruitment. These results indicate that recurrent diabetes is exclusively driven by autoreactive T cells primed during the primary autoimmune response, and demonstrate that local antigen expression is a sine qua non requirement for accumulation of memory T cells into islet grafts. These findings underscore the importance of tackling autoreactive T-cell memory after β-cell replacement therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoantigens / analysis*
  • Autoantigens / genetics
  • Autoantigens / metabolism
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / pathology
  • Cells, Cultured
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / metabolism
  • Diabetes Mellitus, Type 1 / pathology
  • Diabetes Mellitus, Type 1 / therapy*
  • Epitopes
  • Glucose-6-Phosphatase / analysis
  • Glucose-6-Phosphatase / genetics
  • Glucose-6-Phosphatase / metabolism
  • Graft Survival
  • Immunologic Memory*
  • Islets of Langerhans Transplantation / adverse effects
  • Islets of Langerhans Transplantation / immunology*
  • Islets of Langerhans Transplantation / pathology
  • Kidney
  • Lymph Nodes / immunology
  • Lymph Nodes / metabolism
  • Lymph Nodes / pathology
  • Mice
  • Mice, Inbred NOD
  • Mice, Transgenic
  • Pancreas / immunology
  • Pancreas / metabolism
  • Pancreas / pathology
  • Peptide Fragments / analysis
  • Peptide Fragments / genetics
  • Peptide Fragments / metabolism
  • Proteins / analysis
  • Proteins / genetics
  • Proteins / metabolism
  • Spleen / immunology
  • Spleen / metabolism
  • Spleen / pathology
  • Transplantation, Heterotopic / adverse effects
  • Transplantation, Heterotopic / immunology*
  • Transplantation, Isogeneic / adverse effects
  • Transplantation, Isogeneic / immunology

Substances

  • Autoantigens
  • Epitopes
  • Peptide Fragments
  • Proteins
  • Glucose-6-Phosphatase
  • G6pc2 protein, mouse