Abstract
Mice and guinea pigs were immunized with the haemagglutinin (HA) of influenza B-USSR/100 virus, either in Syntex Adjuvant Formulation-1 (SAF-1) or in saline. Antibody titres were determined by ELISA, haemagglutination inhibition and virus neutralization. Animals immunized with HA in SAF-1 had significantly higher antibody titres than did animals immunized with HA in saline. Both 3-week-old and 13 1/2-month-old mice had greater and more uniform antibody responses to HA in SAF-1 than to HA in saline.
MeSH terms
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Adjuvants, Immunologic*
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Aging / immunology
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Animals
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Antibodies, Viral / biosynthesis*
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Dose-Response Relationship, Immunologic
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Enzyme-Linked Immunosorbent Assay
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Female
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Guinea Pigs
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Hemagglutination Inhibition Tests
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Hemagglutinins, Viral / immunology*
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Immunization, Secondary
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Immunoglobulin A / biosynthesis
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Immunoglobulin G / biosynthesis
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Immunoglobulin M / biosynthesis
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Influenza B virus / immunology*
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Influenza Vaccines / immunology*
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Mice
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Mice, Inbred BALB C
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Neutralization Tests
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Skin Tests
Substances
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Adjuvants, Immunologic
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Antibodies, Viral
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Hemagglutinins, Viral
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Immunoglobulin A
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Immunoglobulin G
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Immunoglobulin M
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Influenza Vaccines